The Adaptor Protein soc-1/Gab1 Modifies Growth Factor Receptor Output in Caenorhabditis elegans
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چکیده
منابع مشابه
The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-gamma (PLCgamma) and phosphatidylinosi...
متن کاملThe adaptor protein soc-1/Gab1 modifies growth factor receptor output in C. elegans
Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK) stimulated Ras/Map kinase signaling, through the recruitment of csw/ptp-2/Shp2. Using sensitised assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (Insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-γ (PLCγ) and phosphatidylinositol 3’-...
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The components of receptor tyrosine kinase signaling complexes help to define the specificity of the effects of their activation. The Caenorhabditis elegans fibroblast growth factor receptor (FGFR), EGL-15, regulates a number of processes, including sex myoblast (SM) migration guidance and fluid homeostasis, both of which require a Grb2/Sos/Ras cassette of signaling components. Here we show tha...
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In addition to contractile function, muscle provides a metabolic buffer by degrading protein in times of organismal need. Protein is also degraded during adaptive muscle remodeling upon exercise, but extreme degradation in diverse clinical conditions can compromise function(s) and threaten life. Here, we show how two independent signals interact to control protein degradation. In striated muscl...
متن کاملsoc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
Activation of fibroblast growth factor (FGF) receptors elicits diverse cellular responses including growth, mitogenesis, migration, and differentiation. The intracellular signaling pathways that mediate these important processes are not well understood. In Caenorhabditis elegans, suppressors of clr-1 identify genes, termed soc genes, that potentially mediate or activate signaling through the EG...
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ژورنال
عنوان ژورنال: Genetics
سال: 2006
ISSN: 1943-2631
DOI: 10.1534/genetics.106.055822